Structure of calcium-free mannose-binding protein

بررسی سطح سرمی C–Reactive Protein Mannoseو Mannose–Binding Lectin در افراد مبتلا به درماتوفیتوزیس

Background: Interleukin8 (IL-8) realized from keratinocytes in the presence of dermatophytic antigens causesinduction of acute responses in dermatophyte infection and subsequently production of acute phaseproteins occurs in hepatocytes. C–reactive protein (CRP) and Mannose–binding lectin (MBL) areacute phase proteins. Since few researches in the case of acute phase proteins in dermatophyticinfe...

Human Mannose-binding Protein Functions

Influenza A viruses (IAVs) cause substantial morbidity and mortality in yearly epidemics, which result from the ability of the virus to alter the antigenicity of its envelope proteins. Despite the rapid replication of this virus and its ability to infect a wide variety of cell types, viremia is rare and the infection is generally limited to the upper respiratory tract. The preimmune host defens...

Expression and Distribution of Calcium-Binding Protein S100P in Human Placenta during Pregnancy

Structure and Calcium Binding Properties of a Neuronal Calcium-Myristoyl Switch Protein, Visinin-Like Protein 3

Visinin-like protein 3 (VILIP-3) belongs to a family of Ca2+-myristoyl switch proteins that regulate signal transduction in the brain and retina. Here we analyze Ca2+ binding, characterize Ca2+-induced conformational changes, and determine the NMR structure of myristoylated VILIP-3. Three Ca2+ bind cooperatively to VILIP-3 at EF2, EF3 and EF4 (KD = 0.52 μM and Hill slope of 1.8). NMR assignment...

The Human Mannose-binding Protein Gene

The human mannose-binding protein (MBP)' is an acute phase serum protein of -300 kD comprised of multimers of a 32-kD subunit (1-3). It is a member of an ever-growing family of animal lectins that share at least 18 invariant residues in their carbohydrate recognition domain (CRD). The family can be divided into membrane proteins and soluble proteins, and all bind ligands optimally at neutral pH...